Wewege MA, et al. - Researchers systematically reviewed randomized controlled studies examining experimentally induced pain before and during/following a single bout of exercise in healthy individuals or people with chronic musculoskeletal pain. Of 5,829 screened records, 13 studies were ultimately included. Aerobic exercise caused large exercise-induced hypoalgesia (EIH) in healthy individuals (7 studies, 236 participants), dynamic resistance exercise caused small EIH (2 studies, 23 participants), and isometric exercise did not cause EIH (3 studies, 177 participants). Isometric exercise did not cause EIH in chronic musculoskeletal pain (3 studies, 114 participants); aerobic (0 studies) and dynamic resistance (1 study) exercise were not analysed in cases with chronic musculoskeletal pain. Per these low-quality data from small samples, aerobic and dynamic resistance exercise can reduce experimental pain in healthy individuals.