Chow PI, et al. - In this secondary data analysis, researchers used three waves of data from the Health and Retirement Study to investigate if the connection between personality change and increased depression would be mediated by increased chronic stressors and decreased physical health in a cancer survivor sample. Among the same subjects, they also investigated if personality change would mediate the link between changes in chronic stressors/health and increased depression. They included 5,217 participants, among whom 707 had a cancer diagnosis. They found that the association between cancer survivor status and depression was not mediated by changes in personality, apart from conscientiousness. Depression may increase among older adult cancer survivors due to worsening physical health and chronic stressors induced by changes in personality traits and could help target interventions. Especially in older adult cancer survivors, a benefit from interventions that target increased neuroticism could be seen.