Coiffard B, Diallo AB, Culver A, et al. - This research sought to present by mathematical modeling an accurate course of core body temperature (CBT) in severe trauma patients and its relation to sepsis. A cohort of severe trauma was conducted to obtain the CBT measurements for 24 h on day 2 after admission and rhythmicity assessed by Fourier transform and Cosinor analysis to describe circadian features (frequency and amplitude). Researchers compared CBT between patients who developed sepsis or not during the early ICU stay. This analysis enrolled a total of 33 individuals. The complex temperature circadian rhythms were exhibited in trauma patients. It was noted that early exacerbation of the temperature rhythmicity (in frequency and amplitude) is correlated with the development of sepsis. In addition, in ICU patients, this observation accentuates the concept of circadian disruption and sepsis.