Jha AK, Neupane P, Pradhan M, et al. - Researchers undertook this first prospective oncologic clinical trial to offer state-of-the-art chemotherapy to patients with Ewing sarcoma in Nepal. They focused on the effectiveness of external-beam radiotherapy (RT) as the sole local treatment modality and on its validity because accessible advanced tumor-orthopedic services in Nepal are lacking. Participants included 20 patients with newly diagnosed Ewing sarcoma, including 11 female and 9 male patients between the ages of 6 and 37 years. These patients were given neoadjuvant combination chemotherapy, including well-established drug combinations, in five courses prior to external-beam RT, during which one course of etoposide and ifosfamide was administered. Following RT, six additional chemotherapy courses were scheduled. They found good tolerability of RT, and rapid symptom relief and local tumor control associated with its use, with no pathologic fractures seen among the 15 patients treated with such treatment. This investigation was feasible with RT as the sole local treatment modality in combination with chemotherapy. No definite conclusions could be reached because of the high number of patients lost to follow-up, however, durable long-term remissions were achieved by the majority of the patients who completed treatment.