Cheng E, et al. - Using data from the prospective Iowa Women's Health Study, researchers investigated associations of evolutionary-concordance diet and Mediterranean diet pattern scores and an evolutionary-concordance lifestyle score (comprising smoking status, physical activity, and body mass index) with incident colorectal cancer (CRC). Calculation of diet and lifestyle scores for each participant and categorization into quintiles was carried out. Using Cox proportional hazards models, associations were estimated. Findings suggested a possible inverse association of a more evolutionary-concordant lifestyle, alone and in interaction with a more evolutionary-concordant diet pattern, with CRC risk.