Lisicki M, et al. - Researchers performed a comparison of resting cerebral glucose uptake [using positron emission tomography (¹⁸fluorodeoxyglucose-positron emission tomography)], and visual cortex activation [using visual evoked potentials (VEP)], between episodic migraine without aura patients in the interictal period and healthy volunteers. In this work, migraine patients displayed an area of increased neuronal activation-to-resting glucose uptake ratio in the visual cortex between attacks. Thereby supporting that in migraine pathophysiology, an activity-induced rupture of cerebral metabolic homeostasis may be a cornerstone.