Melchers RC, et al. - Authors evaluated the effectiveness of conventional treatment strategies for patients with multifocal cutaneous anaplastic large cell lymphoma (C-ALCL) and characterized which patients may need novel targeted therapies. Low-dose RT (2 × 4 Gy) should be used to treat the patients with 5 or less lesions. In patients with more than 5 lesions, maintenance low-dose MTX (20 mg weekly) was an appropriate option. Consideration of targeted therapies was suggested in rare patients who were refractory to MTX or patients developing extracutaneous disease.