Jørstad MD, et al. - Researchers undertook this prospective cohort study of presumptive extrapulmonary tuberculosis (EPTB) patients at Mnazi Mmoja Hospital, Zanzibar in order to describe the clinical presentation of EPTB. In addition, they examined how treatment influences the clinical parameters and assessed if simple clinical parameters, without laboratory data, could evaluate treatment response. They identified 64 tuberculosis (TB) and 62 non-TB cases. TB cases showed a trend towards regression of lymphadenopathy after 2 months. At treatment completion, full regression was noted in 24/28 (86%) cases. In 36/49 (73%) of the TB patients at 2 months and in 38/46 (83%) at treatment completion, ≥5% Weight gain was reported. After 2 months of treatment, treatment response was correlated with a combination of clinical parameters including improvement of symptoms (50/50), ≥5% weight gain (36/49) and regression of physical signs (45/49). An algorithm including these simple clinical parameters seems to have utility as an easy tool to assess treatment responses in low-resource settings.