Xu D, Wu B, Li X, et al. - In patients with acromegaly who presented with growth hormone (GH)-secreting adenoma, researchers conducted this retrospective study to evaluate the features of thyroid nodules before and after surgery. From the outpatient and inpatient department of The First Affiliated Hospital, Jinan University between August 2015 and August 2017, all 134 consecutive candidates with GH-secreting (n = 67) and NF pituitary (n = 67) adenomas were recruited. Using an ultrasound system, thyroid ultrasonography was performed. In patients with GH-secreting adenomas, the numbers of hypoechoic, isoechoic, heterogeneous, and vascular thyroid nodules increased. Surgery resulted in significant changes from solid to cystic nodules in these patients and also decreased the number of heterogeneous and vascular thyroid nodules. The reason for these modifications may be due to reduced GH levels after pituitary GH adenomas have been resected, leading in reduced proliferation of thyroid cells and enhanced apoptosis.