Izgi M, et al. - The combination of propofol and ketamine is commonly used for total intravenous anesthesia. It was hypothesized that when these drugs are mixed in 1 syringe, they might separate and different concentrations of each drug could be found in different parts of the syringe during the procedure period. In this current study, it was shown that mixtures of propofol (1% and 2%) and ketamine at 5:1 and 6.7:1 ratios could be used in terms of mixture homogeneity and stability in a polypropylene syringe during a 6-hour period at room temperature.