Navarrete-Dechent C, et al. - In this case report study of two patients with locally advanced primary melanomas, researchers examined if reflectance confocal microscopy (RCM) is feasible for monitoring advanced melanomas treated with immunotherapy. Outcomes support a good correlation of reflectance confocal microscopy with the clinical and histopathologic findings. This supports its possible role in the treatment monitoring of these patients. RCM holds promise as a novel noninvasive technique for imaging of cutaneous involvement and disease monitoring, even though it cannot replace larger field imaging (such as magnetic resonance imaging, positron emission tomography, and computed tomography) in the management and follow-up of melanoma or other tumors.