Finocchario-Kessler S, et al. - HIV Infant Tracking System (HITSystem) was evaluated for its efficacy on key outcomes of early infant diagnosis via performing a cluster-randomized trial at six hospitals in Kenya, which were matched on geographic region, resource level, and volume of patients (high, medium, and low). Hospitals within a matched pair were randomly allocated to either the HITSystem (intervention; n=3) or standard of care (control; n=3). Analyzing data from 690 mother-infant pairs, of whom 392 were allocated to the HITSystem and 298 to the standard of care, they noted significantly higher likelihood of receiving complete early infant diagnosis services for infants enrolled in the HITSystem compared with those assigned standard of care (334 of 392 [85%] vs 180 of 298 [60%]). Despite recording no intervention effect at high-volume hospitals, they observed strong effects at medium-volume and low-volume hospitals. Findings thus suggest HITSystem intervention as effective and feasible to implement in low-resource settings. Modification in the HITSystem algorithms to include HIV testing at birth was done, and an adapted HITSystem 2.0 version is supporting HIV-positive pregnant women to check perinatal transmission and optimize maternal and infant outcomes.