Kovatcheva RD, Shinkov AD, Dimitrova ID, et al. - Researchers conducted this single-center prospective study to assess the performance of European Thyroid Imaging Reporting and Data System (EU-TIRADS) in identifying thyroid nodules for fine-needle aspiration biopsy (FNAB) and its ability to minimize the number of unnecessary biopsies. Seven hundred eighty-three consecutive patients with 1,000 thyroid nodules had US examination and US-guided FNAB from August 2017 to September 2018. In total, 741 patients (median age 50 years; range, 15–87 years; 649 females, 92 males) with 942 nodules (median largest diameter 14 mm; range, 4–96 mm) met the criteria for inclusion. Data reported that sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of EU-TIRADS with a cut-off set at category 5, respectively, were 91.3, 74.6, 30.6, 98.6, and 76.4%. According to results, EU-TIRADS offers successful risk stratification for malignancy which can direct the selection of thyroid nodules for biopsy. The implementation of the FNAB guidance requirements in clinical practice will greatly reduce the number of unnecessary FNABs.