Hanson M, McGill M, Mimica X, et al. - It is necessary to consider individual histologic risk when planning adjuvant radiotherapy in salivary gland cancer patients with close margins; observation post-surgery could be an acceptable form of management in cases with low-risk histologic-type disease.

• This is a cohort study of 837 patients with surgically treated salivary gland cancer.

• An elevated risk for poorer local control and survival was observed in patients with either close or positive surgical margins.

• Patients with positive surgical margins showed better outcomes with postoperative adjuvant radiotherapy.

• Margin status was not an independent factor linked with poorer results, post-controlling for tumor stage, histologic risk group, and the use of adjuvant radiotherapy.

• Among patients with close margins who had low-risk histologic-type and low-stage I/II disease, comparable local control was found between those who did not vs who did receive adjuvant radiotherapy.