Gao Y, Huo S, Sun M, et al. - Although the etiopathogenesis of alopecia areata (AA) is unknown, it is critical to monitor the levels of T3, T4, TPOAbs, antinuclear antibodies (ANA), and 25 (OH)D in AA patients.

• From January 2016 to May 2020, 672 eligible AA patients and 580 age- and sex-matched healthy people were treated at a third-class hospital in Hefei.

• This study collected data on serum C-reactive protein (CRP), 25-hydroxy vitamin D (25(OH)D), T3, T4, thyroid‑stimulating hormone (TSH), thyroid antibodies (TPOAbs and TGAbs), ANA, complements (C3, C4), and several immunoglobulins (IgA, IgM, and IgG).

• In terms of autoimmune-related functional indicators, there were no statistically significant differences between AA patients and healthy controls in TSH, TGAbs, C3, C4, IgA, IgM, and IgG levels.

• Only T3, T4, TPOAbs, and ANA values were significantly abnormal in the AA group than in the healthy people.

• Furthermore, the mean serum 25(OH)D concentration in the patient group was significantly lower than in the control group, but serum CRP was significantly higher.