Muirhead CA, Lanocha N, Markwardt S, et al. - Given that antimicrobials, airway clearance, and nutrition represent the mainstay of therapy in an acute pulmonary exacerbation (APE) in cystic fibrosis (CF), however, addition of corticosteroids to therapy has been done when patients failed to improve, researchers herein retrospectively assessed rescue steroids use in a children's hospital from 2013 to 2017 during CF APE treatment after at least 1 week of inpatient treatment without expected clinical improvement. Less improvement at midpoint percent change from admission in FEV1 percent predicted (FEV1pp) was observed in encounters managed with steroids vs nonsteroid group change in FEV1pp. Also, experts assessed propensity matching, comparing results in patients without midpoint improvement in FEV1pp. They found that admission or discharge FEV1pp did not differ between groups. Overall, findings indicate that essential outcome measures during CF APE treatment were not predictably affected by rescue use of corticosteroids during APE.