Bjørke AB, et al. - In patients with temporal lobe epilepsy, researchers assessed risk factors for drug resistance and polypharmacy. Participants in the study had been treated for temporal lobe epilepsy for more than 5 years and completed questionnaires on antiepileptic drug use and effect. They used logistic regression models for analysis of risk factors. The only early risk factor for drug resistance found in this study was a poor effect from initial pharmacotherapy. It was noted that disease duration was correlated with annual risk for drug resistance of 7% and for polypharmacy of 5%. They found that second-generation antiepileptic drugs provided no additional effect for poor responders to first-generation drugs.