Kochar B, et al. – Researchers performed this study to assess the gastrointestinal (GI) patient reported outcome (PRO) Measurement Information System (PROMIS) in inflammatory bowel diseases (IBD) subjects. GI–PROMIS domains were strongly correlated with disease activity and quality of life (QoL) indices in IBD subjects experiencing GI symptoms. In IBD, GI–PROMIS held potential as PRO measures and correlated with other validated indices in this population.

• Crohn’s and Colitis Foundation of America’s Partners included an Internet-based cohort of IBD individuals.
• For this study, participants completed surveys, including demographics, disease characteristics, PROMIS domains, disease activity (short Crohn's disease activity index or simple clinical colitis activity index) and quality of life (QoL) indices.
• Univariate and bivariate analyses were used to evaluate associations between 8 GI-PROMIS domains (reflux, swallowing, diarrhea, nausea, belly pain, gas, incontinence, and constipation) and QoL and disease activity indices in a nested cross-sectional study.

• With a median age of 41 years, the researchers included 2,378 Crohn's Disease (CD) and 1,455 ulcerative colitis (UC) respondents.
• For CD subjects, median disease duration was 11 years and 8 years for UC subjects; 57% of CD subjects and 42% of UC subjects were in remission.
• Those with active CD reported significantly worse symptoms on all 8 domains than those in remission among symptomatic CD subjects.
• They observed the same for UC subjects with the exception of disrupted swallowing.
• Compared to those with better QoL, IBD subjects with worse QoL reported significantly worse symptoms on all 8 domains.