Juárez-Rendón KJ, et al. - In the Mexican population, a study evaluating the presence of mutations or polymorphisms in BMP15, FSHR, FOXL2, and GDF9 genes was performed for the first time. Two polymorphisms were identified: a coding change, c.919G>A (p.Ala307Thr), in the FSHR gene and a synonymous variant, c.447C>T (p.Thr149Thr), in the GDF9 gene. No significant difference associated with primary ovarian insufficiency (POI) in the patients when compared with a healthy control group was noted. In this sample of Mexican women, the lack of association of the evaluated genes was consistent with the complex genetic etiology of POI that is observed across cohorts studied thus far.