Scott R, et al. - It was determined if a fixed dose of 1000 IU of a four-factor prothrombin complex concentrate (PCC4) achieves international normalized ratio (INR) reversal similar to weight-based dosing in patients with intracranial hemorrhage (ICH) who were anticoagulated with warfarin. A non-statistically significant difference was observed in warfarin reversal to an INR goal of < 1.5 when compared with a fixed dose of 1000 IU PCC4 and a weight-based dose for ICH.