Nagata G, et al. - Experts evaluated the different grades of dysplasia in the epithelium adjacent to lip squamous cell carcinoma (LSCC), as a parallel to actinic cheilitis (AC) that suffered malignant transformation. In the epithelium adjacent to LSCC, heterogeneous grades of epithelial dysplasia were observed, thereby suggesting the insufficiency of the analysis of AC morphological features to predict patient's prognosis and to determine a treatment decision. This idea was reinforced by the positive expression of mutant p53 in mild dysplasia.