Tjalsma AS, Wagner A, Dinjens WNM, et al. - In 2016, a nationwide guideline was introduced in the Netherlands recommending routine Lynch syndrome screening (LSS) for all women with endometrial cancer (EC) < 70 years of age. The implementation of this guideline has been evaluated in this study. All women diagnosed with EC < 70 years of age, treated from the period July 2016 to July 2017 in 14 hospitals were selected from the nationwide pathology database. LSS was performed in 183 out of 204 tumors (90%). Although coverage of LSS was high, there is possibility for improvement in implementation of Lynch syndrome screening in endometrial cancer. Based on outcomes, they emphasize gynecologists should be aware of the advantages and possible drawbacks of recognizing mutational status, and they may need training in discussing this with their patients. Implementation of quality assurance protocols was emphasized to ensure adherence to Lynch syndrome screening in endometrial cancer.