Huffman MD, et al. - In the Mediators of Atherosclerosis among South Asians Living in America (MASALA) cohort of participants who were free from clinical ASCVD at baseline, researchers assessed the distribution of Lp(a) levels, and evaluated the cross-sectional link with atherosclerosis assessed by coronary artery calcification (CAC) and carotid intima media thickness (CIMT) in overall 886 participants (mean [SD] age: 55.4 [9.4] years, 54% male), median lipoprotein (a) level was 17 (9, 33) mg/dl. Individuals in the highest Lp(a) quartile (33-178 mg/dl) vs those in the lowest quartile (9 mg/dl) were more likely to be women (51% vs 37%, p<0.01) and had a higher mean (SD) total cholesterol (193 [37] mg/dl vs 181 [35] mg/dl, p<0.01). Findings revealed no association of Lp(a) quartile with prevalent CAC (p=0.98), internal carotid IMT (p=0.46) or common carotid IMT (p=0.97), after adjustment for cardiovascular risk factors. Higher mean Lp(a) levels were detected among South Asian Americans vs previous reports among Whites, Hispanic/Latino, and Chinese-Americans, however, compared in Blacks, these levels were lower. Overall, Lp(a) levels were not related to atherosclerosis among South Asian Americans.