Maeda T, et al. - Authors performed this study to examine the impact of a “no-TXA-use” policy by comparing the adverse effects of TXA and clinical outcomes before and after the policy change in patients undergoing cardiovascular surgery. After the policy change, no change in the mortality rate was observed in spite of decreased seizure rate. Increase in blood loss volume and transfusion volume was evident after the policy change. Advantageous benefit observed with TXA use was a reduction in the need for blood transfusion.