Evaluating agreement, histological features and relevance of separating pleomorphic and florid lobular carcinoma-in-situ subtypes
Human Pathology May 24, 2018
Singh K, et al. - Researchers assessed inter-observer agreement amongst breast pathologists in diagnosing lobular carcinoma in situ (LCIS) subtypes and use the agreement data to justify LCIS classification for management purposes. For this analysis, six breast pathologists independently reviewed 50 hematoxylin and eosin stained slides comprised of a mix of LCIS subtypes. They showed moderate and substantial agreement in diagnosing pleomorphic and florid LCIS respectively. They observed that objective histological features linked with aggressive behavior were more frequent with florid-type LCIS (FLCIS). Findings revealed that pleomorphic-LCIS (PLCIS) and FLCIS patterns frequently coexist, contain similar molecular aberrations, and were managed similarly (like ductal carcinoma in situ {DCIS}). Therefore combining FLCIS and PLCIS into one category (non-classical LCIS) should be considered.
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