Raffaele V, Carlo P, Marcello C, et al. - Researchers assessed the link between femur fracture and euthyroid sick syndrome (ESS) and postoperative changes of the parathyroid hormone (PTH) and vitamin D and their physio-pathological implications. For this study, experts recruited all patients (older than 65 years) who were admitted to the emergency care unit because of proximal femur fractures. Among 45 enrolled patients, a normal thyroidal function in 20 patients and a diagnosis of ESS in 23, respectively, were reported. A significantly higher reduction in Vitamin D levels was noted in the ESS group vs controls. As for PTH, significantly different values were detected between the two groups, with a level 44.29 pg/ml lower among the ESS group vs controls. A significant reduction of serum calcium was noted on the first postsurgery day in the ESS group vs controls. Findings revealed that ESS affected part of the geriatric people who had fractures of the proximal femur. Anomalies of the Vitamin D-PTH axis and a lower BMI were present in this population.