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Eukaryotic viruses in the faecal virome at the onset of type 1 diabetes: A study from four geographically distant African and Asian countries

Pediatric Diabetes Apr 04, 2021

Cinek O, Kramna L, Odeh R, et al. - Because previous studies of the faecal virome in type 1 diabetes (T1D) have been limited to populations in Europe and the USA, researchers sought to describe the stool virome in children after the onset of T1D and in matched control individuals from four geographically distant African and Asian countries. Stool samples were obtained from 73 children and adolescents shortly after T1D onset (Azerbaijan 19, Jordan 20, Nigeria 14, Sudan 20) and 105 matched control individuals of similar age and locale. To model associations with eukaryotic virus positivity, conditional logistic regression was used. In the faecal viromes of four distant non-European populations, no clear and consistent association with T1D was noted. The discovery of borderline human endogenous retrovirus associations warrants further investigation.

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