Yang B, et al. - Researchers intended to gain insight into the severity profile of enterovirus A71 (EV-A71) infections. They attempted to reconstruct the severity profile in a unified framework and for this purpose, they formulated a hierarchical Bayesian model. This model was used to synthesize data on EV-A71 related diseases/events and EV-A71 antibody responses to infection among unvaccinated children from large clinical trials of EV-A71 vaccination which were conducted in Jiangsu and Beijing during 2012 and 2013. Mostly, mild EV-A71 infections were seen in young children. Hospitalized infected patients comprised 2.2% of the overall study population. Post-infection increases in antibody titers were ≥4-fold in nearly 70% of children. With regard to the immune response after infection and the duration of immunity against EV-A71 re-infection, several uncertainties still remain.