Zabala A, Darsalia V, Lind M, et al. - Findings revealed an increased risk of stroke and death in type 2 diabetes (T2D) patients in relation to the presence of a low estimated glucose disposal rate (eGDR) (a measure of insulin resistance). The relative attributed risk was most essential for hypertension.

• This is a nationwide population based observational cohort study with 104,697 T2D patients.

• In patients with eGDR categories between 4–6, 6–8 and > 8, the estimated hazard ratios (HRs) (95% CI) for stroke, post-multivariate adjustment, were : 0.77 (0.69–0.87), 0.68 (0.58–0.80) and 0.60 (0.48–0.76), relative to the reference < 4.

• For the risk of death, corresponding numbers were estimated to be: 0.82 (0.70–0.94), 0.75 (0.64–0.88) and 0.68 (0.53–0.89).

• For each variable in the eGDR formula and stroke, the attributed relative risk R2 (± SE) was for: hypertension (0.045 ± 0.0024), HbA1c (0.013 ± 0.0014), and waist (0.006 ± 0.0009), respectively.