Al-Ahmad M, et al. - A series of patients with acute coronary syndrome undergoing ASA desensitization prior to stenting was assessed with respect to short- and long-term efficacy and safety. The outcomes of an ASA desensitization protocol was developed based on the guidelines proposed by the EAACI drug allergy expert recommendations. The protocol proposed herein addressed challenge or desensitization with the contribution of a specialist allergist. An effective, dynamic, safe, and short administration of 81 mg or higher of ASA in patients with a history of NSAID hypersensitivity with skin involvement was recommended.