Martorell M, et al. - Experts aspired to determine the effects of caloric restriction (CR) on erythrocytes lipid composition. Moreover, they compared and correlated these changes with skeletal muscle acid profiles after CR. Findings revealed that CR modified erythrocyte lipid composition, essentially omega-6 fatty acids (FAs). Factors that significantly positively correlated with skeletal muscle FAs were erythrocyte monounsaturated, polyunsaturated and omega-6 FAs but not the saturated and omega-3 FAs. A discordance was noted between saturated and omega-3 FAs from erythrocyte and from muscle. However, monounsaturated, polyunsaturated and omega-6 fatty acids were positively associated.