Limoncin E, et al. – The aim of this work was to conduct a systematic review and meta–analysis of data on 2317 men treated with phosphodiesterase type 5 inhibitor (PDE5I) after nerve–sparing radical prostatectomy (NSRP). Recent research does not support the hypothesis that PDE5I use recovers drug–unassisted erectile function (EF), while chronic low–dose tadalafil administration may help to preserve erectile tissue integrity. Potential shortcomings in the trials design may partially explain these disappointing results and several questions concerning the recovery of drug–unassisted EF remain unanswered.