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Epstein-Barr virus infection is associated with a higher Child-Pugh score and may predict poor prognoses for patients with liver cirrhosis

BMC Gastroenterology Jun 23, 2019

Hu J, et al. - In patients with liver cirrhosis, researchers determined Epstein-Barr virus (EBV), a γ-human herpesvirus, infection rates, the influence on liver function, and examined the risk factors for death. Between 1 January 2014 and 31 December 2016, the records of patients diagnosed with liver cirrhosis were reviewed. Participants in the study were patients who were or were not infected with EBV. By univariate and multivariate logistic regression, the risk factors for 28-, 90-, and 180-day mortality rates were investigated. According to findings, patients with cirrhosis of the liver had higher rates of EBV infection, particularly patients > 60 years of age who were likely to reflect viral reactivation. And in patients infected with EBV, liver injury has been exacerbated. Thus, through increasing the Child-Pugh score and ACLF rate, EBV infection indirectly influenced the prognosis of EBV-infected patients.
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