Kishimoto S, et al. - In patients with idiopathic hyperaldosteronism (IHA), researchers determined how vascular function in the macrovasculature and microvasculature, arterial stiffness and Rho-associated kinase (ROCK) activity were influenced by eplerenone. They administered eplerenone in 50 patients with IHA and prior to and following 12 weeks of treatment, they measured vascular function, including reactive hyperemia index (RHI), flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID), arterial stiffness including brachial–ankle pulse wave velocity (baPWV) and brachial intima–media thickness (IMT) and ROCK activity in peripheral leukocytes. As a result of treatment with eplerenone, improved microvascular endothelial function, vascular smooth muscle function, arterial stiffness and ROCK activity were observed in patients with IHA.