Hatami B, et al. - The goal of this trial was to determine whether or not the combination of indomethacin and epinephrine in comparison to the single administration of indomethacin varied in the pathogenesis and prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Patients were randomized in a double-blinded manner into 3 groups: The epinephrine group (group A), the indomethacin group (group B), and the combined epinephrine and indomethacin group (group C). In contrast with the administration of indomethacin alone, a single application of epinephrine and the combination of epinephrine and indomethacin was discovered to be effective in reducing the cases of post-ERCP pancreatitis (PEP).