Jouffroy R, et al. - Considering the recommendation of epinephrine for the treatment of non-shockable out of hospital cardiac arrest (OHCA) to obtain return of spontaneous circulation (ROSC), researchers sought to delineate the association between the cumulative dose of epinephrine and the failure of ROSC during the first 30 min of advanced life support (ALS). Findings suggested that total cumulative epinephrine dose administered during OHCA resuscitation was associated with ROSC, with a threshold of 7 mg, best identifying patients with refractory OHCA. To guide the termination of ALS and early decide on the implementation of extracorporeal life support or organ harvesting in the first 30 min of ALS, this threshold can be used.