Hopia L, et al. - In this investigation involving 440 patients, researchers studied the epilepsy prevalence in a hospital-based systemic lupus erythematosus (SLE) cohort and examined the link between epilepsy and other manifestations of neuropsychiatric SLE (NPSLE). The study sample consisted of SLE patients selected from 1998 to 2012. Data reported that 14% were dead and 2.7% were lost to follow-up. In NPSLE patients with epilepsy compared with NPSLE patients without epilepsy, the rates of cerebrovascular disease and psychosis were increased two- and three-fold, respectively. Antiphospholipid syndrome was more common in patients with epilepsy than in patients with or without NPSLE with epilepsy-free SLE. No other etiology than SLE was identified in 50% of patients with epilepsy. The results support the notion of a multifactorial epilepsy history in SLE that involves both vascular disease and autoimmunity-consistent features.