Somboon T, et al. - Authors assessed the recognized clinical, neurobiological, electrophysiologic, and polysomnographic associations between sleep-disordered breathing and epilepsy. They illustrated that central apnea, oxygen desaturations, and hypercapnia could take place during the ictal and immediate postictal period, primarily with generalized tonic-clonic seizures. Such respiratory disturbances might be due to activation of the central autonomic network and may contribute to sudden unexpected death in epilepsy (SUDEP), the leading cause of epilepsy-related death in people with drug-resistant epilepsy. They explained vagus nerve stimulation, a form of neuromodulation for drug-resistant focal epilepsy, can reduce airflow and respiratory effort, obstruct airflow, and cause oxygen desaturations, which can create a clinical sleep apnea syndrome when the device activates during sleep.