Opfermann P, Wiener C, Schmid W, et al. - Researchers assessed thoracic epidural anesthesia, vs general anesthesia, for open infantile hypertrophic pyloric stenosis surgery, focusing on desaturation events (≤ 90% oxygen saturation) and absolute values of minimal oxygen saturation, minimal heart frequency, operating‐room occupancy time, and durations of surgery in this retrospective analysis. There were 69 and 32 evaluable infants in the epidural and general anesthesia groups, respectively. Cumulatively higher minimimal mean (SD) oxygen saturation values as well as lower minimal mean (SD) heart rate values over time were detected in patients who received epidural anesthesia. In this series, fewer desaturation events ≤ 90% occurred in relation to maintaining spontaneous breathing with minimal airway manipulation in patients receiving open repair of hypertrophic pyloric stenosis under single‐shot epidural anesthesia vs general anesthesia. Additionally, shorter turnover times in the operating room seemed to be conferred by this approach.