Chong SL, et al. - Trends in fatalities and injuries after pedestrian–motor vehicle collisions in the U.S. were described and associated risk factors for pedestrian fatalities were identified. Researchers in this cross-sectional study of U.S. pedestrian–motor vehicle collisions from 2006 to 2015 (performed in 2017) identified 47,789 pedestrian fatalities and 674,414 injuries. Elderly aged 85 years and older exhibited highest fatality rates, whereas those aged 15–19 years exhibited highest injury rates. Predictors associated with increased risk for death were: male sex, age ≥65 years, alcohol involvement, collisions after midnight, at non-intersections, and involving trucks and buses. Interventions including elder-friendly intersections and increasing visibility of pedestrians might help in reducing pedestrian injuries and deaths.