Faustino EVS, et al. - A multicenter, prospective, cohort study was performed to ascertain the epidemiology of lower extremity deep venous thrombosis (DVT) in critically ill adolescents. Eligibility criteria were adolescents aged 13-17 years who were admitted to 6 Pediatric Intensive Care Units and were anticipated to receive cardiopulmonary support for at least 48 hours, unless they were admitted with DVT or pulmonary embolism or were receiving or anticipated to receive therapeutic anticoagulation. This investigation highlighted the similarities and differences in the epidemiology of DVT between adults and adolescents. In critically ill adolescents, they supported the conduct and informed the design of a trial of pharmacologic prophylaxis.