Siew JX, Seah XFV, Chew YR, et al. - Since 2013, hospitalized children in Singapore had an increase in human adenovirus (HAdV) infections. Severe HAdV infections were observed in correlation with young age (< 2 years) and significant comorbidities. Given the limited data and efficacy of cidofovir (CDV), which was used to treat severe HAdV infections, researchers sought to report on clinical characteristics, potential risk factors for mortality, as well as on the outcome of cases treated with CDV. They identified a total of 1,167 children who were admitted for HAdV infection; 85 of these (7.3%) were severe. The median age was 1.5 years for severe infections. Comorbidities were evident (69.4%) and pneumonia was noted at presentation (32.9%), in the majority. Pediatric patients with severe HAdV infections can exhibit high mortality. The most common genotypes identified were HAdV-7 and HAdV-3 in this cohort with severe HAdV infection. The potential risk factor for mortality was pneumonia in severe HAdV infections in this cohort. Based on observations, they suggest considering early CDV administration in patients with severe HAdV infection and existing comorbidities.