Chaaban MR, et al. - As no study has examined the epidemiology of anaphylaxis after introduction of the codes of the International Statistical Classification of Diseases and Health Related Problems, Tenth Revision, Clinical Modification (ICD-10 CM), researchers undertook the first population-based study examining the trends in incidence and hospitalization rates in the United States utilizing ICD-9 and ICD-10 CM codes. Using the Clinformatics database from 2004 to 2016, they identified a total of 462,906 anaphylaxis cases. Increase in the incidence from 153 in 2004 to 218 in 2016 (per 100,000) were noted. Women were noted to have 1.19 (95% confidence interval, 1.18-1.20) times more tendency to present with anaphylaxis. A 15-fold increase was observed in medication-induced anaphylaxis. ICD-10 codes seemed to enhance the accuracy of medication-induced anaphylaxis, the most likely etiology to result in hospitalization.