Alonso JE, et al. – This paper focused on the epidemiology and survival outcomes of sinonasal verrucous carcinoma in the United States. Verrucous carcinoma of the sinonasal tract was associated with a generally favorable prognosis. Findings displayed that age, primary site, and surgical therapy were independent predictors of overall survival (OS) and disease–specific survival (DSS), respectively.

Methods

• The SEER registry was applied to calculate survival trends for patients with verrucous carcinoma of the sinonasal tract between 1973 and 2014. 
• Patient data then was evaluated in terms of age, sex, race, and treatment modalities (surgery and radiation therapy).
•  Overall survival (OS) and disease–specific survival (DSS) were measured.

Results

• 86 cases of VC of the sinonasal tract were included. 
• Enrolled subjects comprised of 69.8% males.
• 67.4 years was the mean age at diagnosis. 
• The nasal cavity was the most common primary site (51.2%), followed by the maxillary sinus (40.7%) and nasopharynx (5.8%). 
• 97.6 months was the median OS.
• 89.5% of cases underwent surgery and 20.9% received both surgery and radiation therapy. 
• Overall survival at 2, 5, and 10 years was 73%, 59%, and 36%, respectively.
• On multivariate analysis, advanced age (P < 0.05) and primary site (P < 0.05) were associated with worse OS and DSS, respectively. 
• Findings suggested that primary nasopharyngeal tumor site was associated with reduced DSS (P < 0.05). 
• Surgery improved OS (P < 0.001) and DSS (P < 0.001).