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Epidemiology and prognostic factors for mycosis fungoides and Sézary syndrome in a multi-ethnic Asian cohort: A 12-year review

Journal of the European Academy of Dermatology and Venereology Aug 27, 2019

Lim HLJ, Tan EST, Tee SI, et al. - Because there is limited information on the survival of Asian patients with mycosis fungoides (MF) and Sézary syndrome (SS), researchers assessed the epidemiology, outcome and prognostic factors of these patients. The study sample consisted of MF/SS cases diagnosed from 2000 to 2011 at a tertiary referral dermatology centre in Singapore. Participants in the study were 246 patients (median age at diagnosis was 49 years). In this retrospective review, 73.2% were Chinese, 12.6% Indian, 6.9% Malay and 7.3% Caucasian. Data reported complete response to treatment occurred in 78.2%, partial response in 9.6%, a persistent but non-progressive disease in 10.0% and disease progression in 4.1% of patients. In 4.1% of patients, large cell transformation occurred. According to results, male gender, early disease stage (T1) at diagnosis and absence of maintenance treatment after remission were prognostic factors linked to favourable recurrence-free survival. MF in South-East Asians was diagnosed at a younger age and associated with lower mortality compared with Caucasian and East Asian cohorts, largely due to a higher prevalence of hypopigmented MF.
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