Miles-Jay A, et al. - Among extraintestinal Escherichia coli collected from US children, researchers assessed the epidemiology and antimicrobial resistance characteristics of the sequence type 131-H30 subclone. Compared to reported estimates among adults, ST131-H30 was less common among extraintestinal E. coli collected from children, possibly reflecting infrequent fluoroquinolone use in pediatrics. However, among extended-spectrum β-lactamase (ESBL)-producing isolates, it was similarly dominant. Relative to other extended-spectrum cephalosporin-resistant E. coli, the H30 subclone seemed disproportionately affecting young children.