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Epidemiological and clinical characteristics of 26 asymptomatic SARS-CoV-2 carriers

The Journal of Infectious Diseases Apr 26, 2020

Pan Y, Yu X, Du X, et al. - Via retrospectively analyzing 26 persistently asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carriers, researchers sought their epidemiological and clinical characteristics. Clustering occurrence was reported in 22 patients (84.6%). From contact to diagnosis and the last positive nucleic acid test, median interval of 19 (8–24 days) and 21.5 days (10–36 days), respectively, was reported. Significant differences were observed in the median period from diagnosis to negative nucleic acid test between cases with normal or atypical chest CT findings (n=16, 61.5%; 7.5 days [2–20 days]) and cases with typical ground-glass or patchy opacities on CT(n=10, 38.5%; 12.5 days[8–22 days]). In seven cases (70.0%) with initial positive nucleic acid test results, they observed a negative result simultaneously with improved CT findings. Three patients (30.0%) exhibited obvious improvement in CT findings despite positive nucleic acid test results. Per findings, asymptomatic patients exhibit small changes in biochemical and inflammatory variables and may show changes on chest CT. Interestingly, SARS-CoV-2 exists for long duration in some asymptomatic patients and there may be necessity for considering false-negative results in SARS-CoV-2 nucleic acid test.

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