Farghaly HS, et al. - Among 32 children with subclinical hypothyroidism (SH) due to autoimmune thyroiditis and 32 healthy children, researchers assessed epicardial fat thickness (EFT) and its relation to early atherosclerotic changes. For this investigation, patients and controls had anthropometric evaluation and measurement of fasting lipids, glucose, insulin, homeostasis model assessment for insulin resistance and high-sensitivity C-reactive protein (hs-CRP). In addition, TSH, free thyroxine (FT4 and FT3) and antithyroid autoantibodies (antithyroid peroxidase and thyroglobulin antibodies) were measured. Investigators found that patients had a higher atherogenic index and hs-CRP compared with controls. In children with SH, EFT was higher than in controls and was associated with FMD responses. In children with SH, measurement of EFT by echocardiography can help to identify those at high risk of developing subclinical atherosclerosis.