Cho H, et al. - Researchers determined whether or not high-potency Nucleos(t)ide analogues (NAs) (entecavir and tenofovir disoproxil fumarate [TDF]) reduce the risk of tumour recurrence more potently than low-potency NAs after curative treatment of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). They noted that antiviral agents with high genetic barrier to resistance (entecavir and TDF) reduced the risk of HCC recurrence compared with other antivirals and no antiviral treatment. This was particularly evident in patients with high baseline viral load.