Tahhan AS, Vaduganathan M, Greene SJ, et al. - Researchers intended to define the representation of older patients, women, and racial/ ethnic minorities in acute coronary syndrome (ACS) randomized trials. For this purpose, they performed a systemic search to identify ACS trials published in 8 major medical journals from January 2001 to December 2018. A total of 1,067,520 patients from 460 trials were analyzed. The results were compared with epidemiologic investigations of patients with ACS. In contemporary ACS trials vs epidemiologic studies, underrepresentation of older patients and women was revealed. A modest improvement in the representation of older patients but not women patients was reported over time. Race/ethnicity data were not afforded by more than three-quarters of trials, and available data indicated a modest rise in the enrollment of nonwhite patients owing to the enrollment of Asian and Hispanic patients. Over time, enrollment of black patients continued to be low.